10 lines
688 B
Plaintext
10 lines
688 B
Plaintext
METAL is a tool for meta-analysis genomewide association scans. METAL can
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combine either (a) test statistics and standard errors or (b) p-values across
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studies (taking sample size and direction of effect into account). METAL
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analysis is a convenient alternative to a direct analysis of merged data from
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multiple studies. It is especially appropriate when data from the individual
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studies cannot be analyzed together because of differences in ethnicity,
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phenotype distribution, gender or constraints in sharing of individual level
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data imposed. Meta-analysis results in little or no loss of efficiency compared
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to analysis of a combined dataset including data from all individual studies.
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